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Regulation of the human allogeneic proliferative response in vitro

โœ Scribed by Edgardo Carosella; Armand Bensussan; Virginia Lepage; Marilyne Sasportes

Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
575 KB
Volume
14
Category
Article
ISSN
0093-7711

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โœฆ Synopsis

We have investigated the glass-wool-adherent characteristics of human lymphocytes able to suppress allogeneic proliferation in vitro. We observed that: (1) Suppressor cells obtained after in vitro priming and their precursors are adherent to glass wool, whereas cytotoxic cells and their precursors are not; (2) primed cells adherent to glass wool are mainly HLA-DR positive, while nonadherent cells are HLA-DR negative or weakly positive; (3) the nonadherent, unprimed T cells used as responder cells in a primary MLR are more readily suppressed by suppressor cells than the same cells unfiltered. This may suggest an enrichment of 'acceptor' cells for suppression.

๐Ÿ“œ SIMILAR VOLUMES

Regulation of the human allogeneic proli
Regulation of the human allogeneic proliferative response in vitro
โœ Marilyne Sasportes; Edgardo Carosella; Armand Bensussan; Constantin Mihaesco; Je ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 695 KB

It has previously been shown that presensitized cells in culture medium release suppressor factors (SF) which can inhibit a primary mixed leukocyte reaction (MLR I). This occurs when the presensitized cells are resensitized with an HLA-DR-specific cell, which can be either the primary stimulator or