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Regulation of the heat-shock response by interferon in mouse L cells

✍ Scribed by M. F. Dubois; V. Mezger; M. Morange; C. Ferrieux; P. Lebon; O. Bensaude

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
885 KB
Volume
137
Category
Article
ISSN
0021-9541

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✦ Synopsis

Interferon (IFN) is not able to induce heat-shock protein (HSP) synthesis. However IFN pretreatment of mouse L cells has been shown to enhance the decrease of overall protein synthesis which follows a heat shock, and to stimulate the accumulation of HSPs. We show here that the synthesis of a protein (the hepatitis B virus surface antigen) under the control of a Drosophila HSP 70 promoter is also stimulated in IFN-pretreated cells. The regulation by IFN takes place at two levels: first, the rate of HSP gene transcription is increased in nuclei isolated from IFN-treated cells; second, the synthesis of HSPs is prolonged after pretreatment with IFN. Experiments performed in the presence of actinomycin D show that this effect is due to a stabilization by IFN of mRNAs coding for HSPs.

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