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Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer

✍ Scribed by Wikman, Harriet ;Kettunen, Eeva


Book ID
120039680
Publisher
Expert Reviews
Year
2006
Tongue
English
Weight
418 KB
Volume
6
Category
Article
ISSN
1473-7140

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The pathway consisting of retinoblastoma protein (pRB), cyclin D1 and p16 (RB pathway) which is involved in the phosphorylation of pRB plays an important role in G 1 /S progression. The disruption of this RB pathway has been reported in several types of human neoplasm. An immunohistochemical study o