## Abstract Elevated deoxycholic acid (DCA), mutations in the adenomatous polyposis coli (__APC__) gene and chronic inflammation are associated with increased risk of colorectal cancer. __APC__ status was manipulated to determine whether DCA mediates inflammatory molecules in normal or initiated co
Regulation of the Adenomatous Polyposis Coli Gene by the miR-135 Family in Colorectal Cancer
β Scribed by Nagel, R.; le Sage, C.; Diosdado, B.; van der Waal, M.; Oude Vrielink, J. A.F.; Bolijn, A.; Meijer, G. A.; Agami, R.
- Book ID
- 127258119
- Publisher
- American Association for Cancer Research
- Year
- 2008
- Tongue
- English
- Weight
- 490 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0008-5472
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Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with