## Abstract Prostate cancer (PCa) cells express vitamin D receptors (VDR) and 1,25‐dihydroxyvitamin D~3~ (1,25(OH)~2~D~3~) inhibits the growth of epithelial cells derived from normal, benign prostate hyperplasia, and PCa as well as established PCa cell lines. The growth inhibitory effects of 1,25(O
Regulation of target gene expression by the vitamin D receptor - an update on mechanisms
✍ Scribed by J. Wesley Pike; Mark B. Meyer; Kathleen A. Bishop
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 331 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1389-9155
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## Abstract Binding of 1α,25‐dihydroxy vitamin D~3~ to the C‐terminal ligand‐binding domain (LBD) of its receptor (VDR) induces a conformational change that enables interaction of VDR with transcriptional coactivators such as members of the p160/SRC family or the DRIP (vitamin D receptor‐interactin