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Regulation of sterol synthesis in human lymphocytes: Evidence for post-transcriptional control by low density lipoprotein

โœ Scribed by Wilhelm Krone; D. John Betteridge; David J. Galton


Book ID
115737698
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
378 KB
Volume
574
Category
Article
ISSN
0005-2760

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Incubation of freshly isolated human mononuclear leucocytes in lipid-depleted serum for 4 h resulted in a two-fold increase in 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity. Insulin, when added to the incubation medium at concentrations of 10 and 100 nmol/l at zero time, caused