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Regulation of steroid 16α-hydroxylation in Streptomyces olivoviridis

✍ Scribed by J. Dlugoński; Prof. Dr. L. Sedlaczek

Book ID: 102910288
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 569 KB
Volume: 21
Category: Article
ISSN: 0233-111X
DOI: 10.1002/jobm.19810210703

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✦ Synopsis

Abstract

The steroid 16α‐hydroxylase of Streptomyces olivoviridis was shown to be constitutive, but synthetized only in small amounts in the absence of cortisol. The induction of the enzyme with the steroidal substrate resulted in a distinct increase in the 16α‐hydroxylation rate. This increase in activity, however, could be demonstrated only in later phases of culturing, after the growth of the mycelium was completed. The possible mechanisms controlling the activity of the enzyme during the growth phase of the culture are discussed.

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