Accommodation of structural rearrangemen
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Wilbur, Jeremy D. ;Hwang, Peter K. ;Brodsky, Frances M. ;Fletterick, Robert J.
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Article
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2010
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International Union of Crystallography
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English
β 682 KB
Huntingtin-interacting protein 1 (HIP1) is an important link between the actin cytoskeleton and clathrin-mediated endocytosis machinery. HIP1 has also been implicated in the pathogenesis of Huntington's disease. The binding of HIP1 to actin is regulated through an interaction with clathrin light cha