✦ LIBER ✦

Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor

✍ Scribed by W. G. Jiang; D. Lloyds; M. C. A. Puntis; T. Nakamura; M. B. Hallett

Publisher: Springer
Year: 1993
Tongue: English
Weight: 637 KB
Volume: 11
Category: Article
ISSN: 0262-0898
DOI: 10.1007/bf00121166

No coin nor oath required. For personal study only.

✦ Synopsis

Hepatocyte growth factor (HGF), also known as scatter factor, regulates both cell motility and the growth of some cell types. We have determined the effects of HGF on the motility and growth of human colon cancer cell lines (HTll5, HT29, HRT18 and HT55). Ceil motility, as measured by dissociation from carrier beads or by scattering of cell colonies, was greatly increased in all cell lines. The effects were completely blocked by anti-HGF antibody. In contrast, cell growth of HTllS, HT29 and HRT18 cells was inhibited by a wide range of concentrations of HGF. HT55 cell growth was also inhibited but needed a prolonged culture period (>5 days). The HGF receptor/Met protein is highly expressed in the membrane fraction of these cells as determined by Western blotting. It is concluded that HGF has an effect on both colon cancer cell motility and growth, which may be important in the control of the spread of colon cancer.

📜 SIMILAR VOLUMES

Hepatocyte growth factor and pancreatic

Hepatocyte growth factor and pancreatic cancer cells

✍ Hirohito Tsubouchi 📂 Article 📅 1999 🏛 Springer Japan 🌐 English ⚖ 43 KB

Proliferation of human colon cancer cell

Proliferation of human colon cancer cells: Role of epidermal growth factor and transforming growth factorα

✍ Shuang Huang; Jose M. Trujillo; Subhas Chakrabarty 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 773 KB

## Abstract Human colon cancer cells produce and secrete a variety of polypeptide growth factors. The functional role of these growth factors, however, is poorly understood. Though the secretion of epidermal growth factor (EGF)‐like activity and EGF‐related molecules by human colon cancer cells in

Amphiregulin and hepatocyte-derived extr

Amphiregulin and hepatocyte-derived extracellular matrix regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability

✍ Isabel Zvibel; Shlomo Brill; Zamir Halpern; Moshe Papa 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 2 views

We studied the effect of two members of the epidermal growth factor (EGF) family-amphiregulin and heparin-binding EGF-like growth factor (HB-EGF)-on cell proliferation, growth factor and growth factor receptor expression, and cell differentiation in two human colon cell lines of varying liver-coloni

Extracellular matrix modulates expressio

Extracellular matrix modulates expression of growth factors and growth-factor receptors in liver-colonizing colon-cancer cell lines

✍ Isabel Zvibel; Zamir Halpern; Moshe Papa 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 210 KB 👁 2 views

Basic fibroblast growth factor stimulate

Basic fibroblast growth factor stimulates hepatocyte growth factor/scatter factor secretion by human mesenchymal cells

✍ Fulvia Roletto; Arturo P. Galvani; Cinzia Cristiani; Barbara Valsasina; Antonell 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 744 KB

## Methods Reagents Human recombinant bFGF, expressed in Eschen'chia coli, was produced and purified in the laboratories of

Epidermal growth factor expression in hu

Epidermal growth factor expression in human colon and colon carcinomas: Anti-sense epidermal growth factor receptor rna down-regulates the proliferation of human colon cancer cells

✍ Sriram Rajagopal; Shuang Huang; Thomas L. Moskal; Bang-Ning Lee; Adel K. El-Nagg 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 961 KB

## Abstract Human colon cancer cell lines express epidermal growth factor (EGF) mRNA, secrete EGF and may respond to it __via__ the cell‐surface EGF receptor (EGFR). Expression of these molecules in human colon and colon tumor, however, is not clear. Reverse transcription‐polymerase chain reaction