Regulation of RUNX2 transcription factor–DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity
✍ Scribed by Karen F Underwood; David R D'Souza; Maria Mochin-Peters; Adam D Pierce; Sravya Kommineni; Moran Choe; Jessica Bennett; Averell Gnatt; Bahru Habtemariam; Alexander D MacKerell Jr.; Antonino Passaniti
- Book ID
- 112118056
- Publisher
- American Society for Bone and Mineral Research
- Year
- 2012
- Tongue
- English
- Weight
- 638 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0884-0431
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Core binding factor alpha 1 (Cbfa1) is an osteoblast-specific transcription factor essential to develop a mature osteoblast phenotype. However, its exact role in the signaling of various osteotropic-differentiating agents is still unclear. In this study, we assessed the effects of 1,25-(OH)(2)-D3 (D
## Abstract The Runx2 transcription factor is a key regulator of osteoblast differentiation. In response to 1α,25 dihydroxy vitamin D3, Runx2 may interact with the 1α,25 dihydroxy vitamin D3 receptor (VDR) in the promoter of target genes, producing a synergic activation of their transcription. Prev