Pulse treatments of U-937 human promonocytic leukemia cells with the DNA topoisomerase-ll inhibitors 4'-(9-acridy-ni1amino)methanesulfon-m-anisidide (amsacrine, mAMSA) or etoposide (VP-16) caused growth inhibition, G2-arrest, increase in cell size and expression of differentiation markers. All these
β¦ LIBER β¦
Regulation of RNA synthesis in higher plant cells by the action of a nucleoside triphosphatase
β Scribed by Klaus Grossmann; Hans-Peter Haschke; Hanns Ulrich Seitz
- Publisher
- Springer-Verlag
- Year
- 1981
- Tongue
- English
- Weight
- 376 KB
- Volume
- 152
- Category
- Article
- ISSN
- 0032-0935
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β¦ Synopsis
The influence of nucleoside triphosphates in relation to divalent cations on RNA synthesis of cells from a suspension culture from parsley was investigated. The data obtained from experiments with isolated nuclei and with an in vitro system with highly purified RNA polymerase I were compared with a chromatin-bound nucleoside triphosphatase activity within the nucleus. The results might suggest a regulatory role of the nucleoside triphosphatase activity in RNA synthesis.
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