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Regulation of ribonucleotide reductase activity and its possible exploitation in chemotherapy

โœ Scribed by Linda Witt; Teresita Yap; Raymond L. Blakley


Book ID
118371867
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
782 KB
Volume
17
Category
Article
ISSN
0065-2571

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Regulation of ribonucleotide reductase a
โœ Joseph G. Cory; Atsushi Sato ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 832 KB

Mammalian ribonucleotide reductase catalyzes the rate-limiting for the de novo synthesis 2'-deoxyribonucleoside 5'-triphosphates. There is some suggestion that this step may also be the rate-limiting step of DNA synthesis. It is apparent that the level of the enzyme, ribonucleotide reductase, varies