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Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

✍ Scribed by Kurokawa, Riki; DiRenzo, James; Boehm, Marcus; Sugarman, Jeffrey; Gloss, Berndt; Rosenfeld, Michael G.; Heyman, Richard A.; Glass, Christopher K.


Book ID
109789935
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
629 KB
Volume
371
Category
Article
ISSN
0028-0836

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## Abstract ## Objective To evaluate the effects of LG100268 (LG268), a synthetic ligand for the nuclear hormone receptor retinoid X receptor, on the expression of matrix metalloproteinase 1 (MMP‐1) and MMP‐13 induced by proinflammatory cytokines in a chondrocyte model. ## Methods SW‐1353 human