Proteinuria in diabetic nephropathy has been correlated with reduction in heparan sulfate proteoglycan (HSPG) content of the glomerular basement membrane. We have previously shown that the underlying mechanism probably involves reduction in the synthesis by glomerular epithelial cells. In this study
Regulation of Rat Glomerular Epithelial Cell Proteoglycans by High-Glucose Medium
โ Scribed by B.S. Kasinath; J.A. Block; A.K. Singh; W.C. Terhune; R. Maldonado; S. Davalath; M.J. Kallgren; L. Wanna
- Book ID
- 115564870
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 946 KB
- Volume
- 309
- Category
- Article
- ISSN
- 0003-9861
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Background Alterations in proteoglycan metabolism are involved in the pathogenesis of diabetic nephropathy. The aim of this study is to evaluate the effects of high glucose on proteoglycan production and to ยฎnd a reliable in vitro model for the study of diabetic nephropathy. Methods A clone of mous
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