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Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells

✍ Scribed by Jean-Marie Sontag; Viyada Nunbhakdi-Craig; Martina Mitterhuber; Egon Ogris; Estelle Sontag


Book ID
111184282
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
792 KB
Volume
115
Category
Article
ISSN
0022-3042

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## Abstract Serotonergic 5‐HT~1A~ receptor signaling leading to nuclear factor‐κB (NF‐κB) activation appears to be critical for cell survival. Adenylyl cyclase and protein kinase A (AC/PKA) are effectors of the 5‐HT~1A~ receptor that are inhibited by GΞ±~i~ subunits. Conversely, GΞ²Ξ³~i~ subunits down