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Regulation of Protein Kinase C βII by Its C2 Domain †

✍ Scribed by Edwards, Amelia S.; Newton, Alexandra C.

Book ID
125961185
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
219 KB
Volume
36
Category
Article
ISSN
0006-2960

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Regulatory domain of human protein kinas
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✍ Amadeo M. Parissenti; Sandra A. Kim; Concettina M. Colantonio; Andrea L. Snihura 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 538 KB

This study demonstrates that the isolated regulatory (R) domain (amino acids 1 -270) of human protein kinase C a (PKCa) is a potent inhibitor of PKCP-I activity in a yeast expression system. The PKCa R domain fused to glutathione-S-transferase competitively inhibited the activity of yeast-expressed