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Regulation of protective immunity against Leishmania major in mice

✍ Scribed by Jacques Louis; Hayo Himmelrich; Carlos Parra-Lopez; Fabienne Tacchini-Cottier; Pascal Launois

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
799 KB
Volume
10
Category
Article
ISSN
0952-7915

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✦ Synopsis

Resolution of lesions induced by Leishmania major in mice results from the development of Thl responses. Cytokines produced by Th 1 cells activate macrophages to a parasiticidal state. The development of Th2 responses in mice from a few strains underlies susceptibility to infection. Cytokines produced by Th2 cells exacerbate the development of lesions because of their deactivating properties for macrophages. This murine model of infection has provided significant insight into the mechanisms intrinsic to the differentiation of disparate CD4+ T cell subsets in viva in animals from different genetic backgrounds.

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