Ornithine decarboxylase (ODC) activity in human breast cancer tissues was correlated with prolactinemia (Prl), estradiol and progesterone cytosol receptors (ER and PR), and histopathologic pattern. Ninety-two cases of breast cancer, six benign mammary disease, and three normal breast tissues were st
Regulation of Prolactin Receptor Levels and Activity in Breast Cancer
β Scribed by G. Swaminathan; B. Varghese; S. Y. Fuchs
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 253 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1083-3021
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Lactogenic hormones which bind to the PRLR are likely to be growth-stimulatory in human breast-cancer cells. Oestrogen and progesterone control cellular expression of the PRLR however, elevated androgen levels in some breast-cancer patients raised the possibility that androgens may also influence br
## Abstract Plasma prolactin levels have been measured in over 4,000 normal women. The relation between hormone levels and age fits a cubic equation. It is suggested that a curve of this nature would generate the observed ageincidence curve for breast cancer, if prolactin were a carcinogen or promo