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Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones

✍ Scribed by Egner, Patricia A.; Kensler, Thomas W.; Prestera, Tory; Talalay, Paul; Libby, Adam H.; Joyner, H. Howard; Curphey, Thomas J.

Book ID
121460006
Publisher
Oxford University Press
Year
1994
Tongue
English
Weight
563 KB
Volume
15
Category
Article
ISSN
0143-3334

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Induction of drug metabolism enzymes and
Induction of drug metabolism enzymes and transporters by oltipraz in rats
✍ Matthew D. Merrell; Lisa M. Augustine; Angela L. Slitt; Nathan J. Cherrington πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 325 KB

## Abstract Coordinate regulation of Phase‐I and ‐II enzymes with xenobiotic transporters has been shown after treatment with microsomal enzyme inducers. The chemopreventive agent oltipraz (OPZ) induces Phase‐I and ‐II drug‐metabolizing enzymes such as CYP2B and NQO1. The purpose of this study was