Regulation of ornithine decarboxylase activity by amino acids, cyclic AMP and luteinizing hormone in cultured mammalian cells
β Scribed by Max Costa; Marco Meloni; Marcia K Jones
- Book ID
- 115747490
- Publisher
- Elsevier Science
- Year
- 1980
- Weight
- 724 KB
- Volume
- 608
- Category
- Article
- ISSN
- 0005-2787
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Primary cultures of cells dissociated from embryonic mouse brain were demonstrated to be a useful system for studying cell proliferation and its regulation. Ornithine decarboxylase activity was closely correlated with the rate of DNA and RNA synthesis during cell growth. suggesting that the enzyme i
## Abstract Ornithine decarboxylase (ODC) inductions by cholera toxin and by the phorbol ester tumor promoter, TPA, were compared in wildβtype Chinese hamster ovary (CHO) cells and in mutant cells having altered cyclic AMPβdependent protein kinase activity. The aim of these studies was to determine