Regulation of nuclear import pathways by vitamin D signalling: Potential biological implications

Signaling of monocytic differentiation b

Signaling of monocytic differentiation by a non-hypercalcemic analog of vitamin D3, 1,25(OH)2-5,6 trans-16-ene-vitamin D3, involves nuclear vitamin D receptor (nVDR) and non-nVDR–mediated pathways

✍ Yan Ji; Xuening Wang; Robert J. Donnelly; Milan R. Uskokovic; George P. Studzins 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB

## Abstract Exposure of leukemia cells to the physiologically active form of vitamin D~3~, 1,25‐dihydroxyvitamin D~3~ (1,25D~3~) normalizes their phenotype to cells that resemble mature monocytes. One of the earliest detectable events in this process is an upregulation of the nuclear receptor for 1