This review summarizes studies on the reciprocal regulation of neuroblastoma neurite outgrowth by thrombin and protease nexin-1 (PN-1). PN-1 recently was shown to possess the same deduced amino acid sequence as the glial-derived neurite-promoting factor. The neurite outgrowth activity of PN-1 depend
Regulation of Neuronal Cells and Astrocytes by Protease Nexin-1 and Thrombin
β Scribed by DENNIS D. CUNNINGHAM
- Book ID
- 119867546
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 541 KB
- Volume
- 674
- Category
- Article
- ISSN
- 0890-6564
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## Abstract Protease nexinβ1 (PNβ1), a potent inhibitor of serine proteases, is present in vascular cells and forms complexes with thrombin, plasminogen activators, and plasmin. We examined the effect of thrombin on PNβ1 expression by rat aortic smooth muscle cells (RASMCs). PNβ1 expression was det
Protease nexin-1 (PN-1) is a protein proteinase inhibitor recently shown to be identical with the glial-derived neurite-promoting factor or glial-derived nexin. It has been shown to promote neurite outgrowth in neuroblastoma cells and in sympathetic neurons. The present experiments were designed to
Prothrombin, thrombin receptor (ThR), and protease nexin-1 (PN-1) mRNA levels in mouse muscle were quantified using competitive reverse transcriptasepolymerase chain reaction during development and after denervation to examine the possible role of thrombin in activity-dependent synapse elimination a