Previously, by using in vivo microdialysis, we demonstrated a huge release of 45Ca2+ from prelabeled tissues to dialysate that was evoked by application of N-methyl-D-aspartate (NMDA) to the rat dentate gyrus (DG) and sector 4 of the cornu ammonis. To establish the mechanism of this phenomenon, in t
Regulation of N-Methyl-d-aspartate receptor-mediated calcium transport and norepinephrine release in rat hippocampus synaptosomes by polyamines
✍ Scribed by Farida Siddiqui; Zafar Iqbal
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 925 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0364-3190
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## Abstract Presynaptic NMDA autoreceptors regulating glutamate release have rarely been investigated. High‐micromolar N‐methyl‐D‐aspartate (NMDA) was reported to elicit glutamate release from hippocampal synaptosomes in a Ca^2+^‐independent manner by reversal of excitatory amino acid transporters.
The nicotinic agonists dimethylphenylpiperainium iodide (DMPP) and carbachol (CARB) as well as (-)nicotine ((-)NIC) were tested alone and in combination with N-methyl-D-aspartate (NMDA) for their abilities to enhance the efflux of 3H-norepinephrine (NE) from slices of rat hippocampus. CARB and (-)NI