✦ LIBER ✦

Regulation of mRNA stability in the nervous system and beyond

✍ Scribed by James S. Malter

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 75 KB
Volume: 66
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.10021

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✦ Synopsis

Abstract

The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence‐specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation. J. Neurosci. Res. 66:311–316, 2001. © 2001 Wiley‐Liss, Inc.

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