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Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study

✍ Scribed by Jensen, Lars Henrik; Rasmussen, Anders Aamann; Byriel, Lene; Kuramochi, Hidekazu; Crüger, Dorthe Gylling; Lindebjerg, Jan; Danenberg, Peter V.; Jakobsen, Anders; Danenberg, Kathleen

Book ID
125385224
Publisher
Springer Netherlands
Year
2013
Tongue
English
Weight
358 KB
Volume
36
Category
Article
ISSN
1570-5870

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## Abstract A cyclin‐dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A