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Regulation of mitochondrial respiration in senescence

✍ Scribed by Jenn C. Chen; Joseph B. Warshaw; D. Rao Sanadi

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
657 KB
Volume
80
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The ADP‐stimulated (State 3) respiration of myocardial mitochondria with glutamate‐malate, glutamate‐pyruvate, palmitylcarnitine and β‐hydroxybutyrate as substrates declined in rats after the age of 20 months. There was no significant decline in pyruvate‐malate, α‐oxoglutarate, palmityl‐CoA, succinate and ascorbate cytochrome c oxidation. Skeletal muscle mitochondria from senescent animals showed a similar decline in glutamate‐malate oxidation but not in palmityl‐CoA, palmitylcarnitine, succinate and ascorbate‐cytochrome c oxidation. The controlled oxidation with ADP‐limiting (State 4) and the ADP/O ratio were not affected. The results indicate an alteration in the subtle regulatory capacity for mitochondrial oxidation in senescent rats. It is suggested that the alteration may be in certain anion transport and associated functions across the mitochondrial membrane or dehydrogenase activity.

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