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Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

✍ Scribed by Ishihara, Naotada; Fujita, Yuu; Oka, Toshihiko; Mihara, Katsuyoshi

Book ID
110031569
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
451 KB
Volume
25
Category
Article
ISSN
0261-4189

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## Abstract To characterize the molecular links between type‐1 autosomal dominant optic atrophy (ADOA) and OPA1 dysfunctions, the effects of pathogenic alleles of this dynamin on mitochondrial morphology and apoptosis were analyzed, either in fibroblasts from affected individuals, or in HeLa cells