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Regulation of mitochondrial gene expression in Trypanosoma brucei

✍ Scribed by Kenneth D. Stuart

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
525 KB
Volume
6
Category
Article
ISSN
0265-9247

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✦ Synopsis

Trypanosoma brucei mitochondria contain unusual small circular DNAs of unknown function. These are catenated with a long informational DNA sequence containing genes homologous to those found in other mitochondria. Although these genes are transcribed throughout the life cycle, diferential production of the mitochondrial respiratory system during the life cycle is accompanied by differential abundance of speciJic transcripts and diferential polyadenylation of mitochondrial gene transcripts. Multiple transcripts occur for most of the mitochondrial genes. Transcripts of the apocytochrome b gene possessing nucleotide sequences at their 5' ends which are not present in mitochondrial DNA are found at stages of the life cycle when the respiratory system is expressed. These results suggest the presence of posttranscriptional mechanisms that regulate the expression of mitochondria1 genes during the life cycle of T. brucei.

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