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Regulation of microglial behavior by ion channel activity

✍ Scribed by Claudia Eder

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
97 KB
Volume
81
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Microglia play an important role in the central nervous system, where these cells, it is believed, have both neuroprotective and neurotoxic effects. In response to acute brain injury or during neurodegenerative and neuroinflammatory diseases, activated microglial cells undergo shape changes, migrate to the affected sites of neuronal damage, proliferate, and release a variety of substances, such as cytokines and reactive oxygen species (ROS). This review summarizes the physiological mechanisms underlying microglial activation and deactivation processes, with particular focus on the involvement of microglial ion channels. Microglial ion channels have been shown to be capable, by regulating membrane potential, cell volume, and intracellular ion concentrations, of modulating or facilitating proliferation, migration, cytokine secretion, shape changes, and the respiratory burst of microglial cells. Β© 2005 Wiley‐Liss, Inc.

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