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Regulation of methotrexate polyglutamate accumulation in vitro: effects of cellular folate content

✍ Scribed by John Galivan; Zenia Nimec; Malgorzata Balinska


Book ID
115776864
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
552 KB
Volume
32
Category
Article
ISSN
0006-2952

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## Abstract ## Objective Methotrexate (MTX) enters cells through the reduced folate carrier (RFC‐1) and exerts part of its effects through polyglutamation to MTX polyglutamates (MTXPGs) and inhibition of 5‐aminoimidazole‐4‐carboxamide ribonucleotide transformylase (ATIC) and thymidylate synthase (