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Regulation of Matrix Metalloproteinase-2 Production by Cytokines and Pharmacological Agents in Human Pulp Cell Cultures

✍ Scribed by Yu-Chao Chang; Shun-Fa Yang; Yih-Shou Hsieh


Book ID
117855566
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
72 KB
Volume
27
Category
Article
ISSN
0099-2399

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Matrix metalloproteinase-2 activation in
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Matrix metalloproteinase-2 (MMP-2) is involved in extracellular matrix remodeling. It is secreted as a proenzyme and activated by membrane type-MMPs (MT-MMP), such as MT1-MMP. In liver fibrosis, MMP-2 is highly expressed in myofibroblasts and may have a profibrogenic role. The mechanisms of its acti