## Abstract Recently, we reported that Src homology 2 domainโcontaining protein tyrosine phosphatase substrate 1 (SHPSโ1) plays an important role in the migration of Langerhans cells (LC). Here, we show that SHPSโ1 is involved in the maturation of LC. Immunofluorescence analysis on epidermal sheets
Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1)
โ Scribed by Julie Blanchette; Issa Abu-Dayyeh; Kasra Hassani; Lorie Whitcombe; Martin Olivier
- Book ID
- 108782413
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 419 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0019-2805
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We have previously shown that the SH2 domain-containing protein tyrosine phosphatase SHP-1 plays a critical role in controlling virus infection in CNS glia in vivo and in vitro. The present study addressed whether increased virus replication in SHP-1-deficient glia in vitro may be a result of altere
## Abstract The protein tyrosine phosphatase SHPโ1 plays an important role in many physiological and pathophysiological processes. This phosphatase is activated through binding of ligands to its SH2โdomains, mainly to the Nโterminal one. Based on a theoretical docking model, backboneโtoโside chain