Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins

Bile acids suppress the secretion of ver

Bile acids suppress the secretion of very-low-density lipoprotein by human hepatocytes in primary culture

✍ Y Lin; R Havinga; H J Verkade; H Moshage; M J Slooff; R J Vonk; F Kuipers 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 318 KB

results show that bile acids strongly interfere with the The existence of a relationship between bile acid and assembly or secretion of VLDL particles by human hepatriacylglycerol metabolism in humans has been estabtocytes, suggesting a physiological function of the enlished, but the underlying mech

Activity and Regulation of Low Density L

Activity and Regulation of Low Density Lipoprotein Receptors in a Human Hepatoblastoma Cell Line

✍ George Y. Wu; Catherine H. Wu; Vincent A. Rifici; Richard J. Stockert 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 605 KB

The responsiveness of low density lipoprotein (LDL) binding and uptake was measured in a human hepatoblastoma cell line, Hep G2. These cells exhibited both saturable, high-affinity and nonsaturable low-affinity components similar to that described for LDL binding in other mammalian cells. In additio

Regulation of Low Density Lipoprotein Re

Regulation of Low Density Lipoprotein Receptor Function in a Human Hepatoma Cell Line

✍ Alan M. Leichtner; Monty Krieger; Alan L. Schwartz 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 638 KB

Low density lipoprotein (LDL) processing was investigated in a human hepatoma-derived cell line, Hep G2. Hep G2 cells bound, internalized and degraded LDL via a saturable, high affinity (Kd -2 x lo-' M ) pathway similar to that present in other mammalian cells. Although 80% of the uptake and degrada

Regulation of Low Density Lipoprotein Re

Regulation of Low Density Lipoprotein Receptor Function in a Human Hepatoma Cell Line

✍ Alan M. Leichtner; Monty Krieger; Alan L. Schwartz 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 599 KB

Low density lipoprotein (LDL) processing was investigated in a human hepatoma-derived cell line, Hep G2. Hep G2 cells bound, internalized and degraded LDL via a saturable, high affinity (Kd -2 x lo-' M ) pathway similar to that present in other mammalian cells. Although 80% of the uptake and degrada

Cellular heterogeneity in binding and up

Cellular heterogeneity in binding and uptake of low-density lipoprotein in primary rat hepatocytes

✍ James P. Corsetti; Janet D. Sparks; Barbara Sikora; Charles E. Sparks 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 766 KB

Hepatocellular heterogeneity of biochemical function is well established for many aspects of liver metabolism. This study addresses the question of cellular heterogeneity in the catabolism of low-density lipoprotein by rat hepatocytes. Low-density lipoprotein binding (4" C) and uptake (37" C) by rat

The relationship between hepatic low-den

The relationship between hepatic low-density lipoprotein receptor activity and serum cholesterol level in the human fetus

✍ Prof. Hai-Jiang Cai; Chong-Lun Xie; Qi Chen; Xiu-Ying Chen; Yue-Hua Chen 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 656 KB

We found that the binding of lzS1-low-density lipoprotein to fetal liver low-density lipoprotein receptor rose progressively with the increase in fetal age. During this period, total cholesterol and low-density lipoprotein-cholesterol levels in fetal serum declined significantly. The correlation coe