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Regulation of JNK by MKK-7 in fibroblast-like synoviocytes

✍ Scribed by Tomoyuki Inoue; Deepa Hammaker; David L. Boyle; Gary S. Firestein

Book ID
101648731
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
302 KB
Volume
54
Category
Article
ISSN
0004-3591

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## Abstract ## Objective The mitogen‐activated protein (MAP) kinase JNK is a key regulator of interleukin‐1 (IL‐1)–induced collagenase gene expression and joint destruction in arthritis. Two upstream kinases, MKK‐4 and MKK‐7, have been identified as potential activators of JNK. However, the role o