Voltage-sensitive calcium channels (VSCCs) mediate signaling events in bone cells in response to mechanical loading. Osteoblasts predominantly express L-type VSCCs composed of the a 1 pore-forming subunit and several auxiliary subunits. Osteocytes, in contrast, express T-type VSCCs and a relatively
✦ LIBER ✦
Regulation of intracellular calcium release and PP1α in a mechanism for 4-hydroxytamoxifen-induced cytotoxicity
✍ Scribed by Aliccia Bollig; Liping Xu; Archana Thakur; Jiusheng Wu; Tuan H. Kuo; Joshua D. Liao
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 395 KB
- Volume
- 305
- Category
- Article
- ISSN
- 0300-8177
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## Abstract Neurotoxicant‐induced elevation of intracellular calcium (Ca^2+^) and modulation by phystoestrogens were examined __in vitro__ using human neuroblastoma SH‐SY5Y cells cultured with amyloid beta‐peptide (A__β__) and 1‐methyl‐4‐phenyl‐pyridine (MPP+). Although A__β__ itself did not increa