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Regulation of interleukin-1β production by glucocorticoids in human monocytes: the mechanism of action depends on the activation signal

✍ Scribed by Mikko Hurme; Pia Siljander; Heli Anttila

Book ID
117055550
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
584 KB
Volume
180
Category
Article
ISSN
0006-291X

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)