The role and mechanisms of action of insulin-like growth factors (IGFs) in skin remain unclear. Epidermal keratinocytes possess IGF-I receptors and are responsive to IGF-I, which is primarily derived from underlying dermal fibroblasts. IGF binding proteins (IGFBPs), also synthesized by fibroblasts,
โฆ LIBER โฆ
Regulation of insulin-like growth factor binding protein release from normal human keratinocytes
โ Scribed by Morhenn, V.; Sasaki, N.; Rosenfeld, R.G.; Neely, E.K.
- Book ID
- 122037366
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 164 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0923-1811
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๐ 2 views
Previously we have shown that transforming growth factor b (TGF b) 1, basic fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) BB inhibit the synthesis of insulin-like growth factor (IGF) II, but their effects on IGF binding protein (IGFBP)-6 in osteoblast cultures are not kno