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Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation

✍ Scribed by Veerle Vanderheyden; Takuya Wakai; Geert Bultynck; Humbert De Smedt; Jan B. Parys; Rafael A. Fissore

Book ID
113525812
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
713 KB
Volume
46
Category
Article
ISSN
0143-4160

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## Abstract At the time of fertilization, an increase in the intracellular Ca^2+^ concentration ([Ca^2+^]~i~) underlies egg activation and initiation of development in all species studied to date. The inositol 1,4,5‐trisphosphate receptor (IP~3~R1), which is mostly located in the endoplasmic reticu

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Calcium (Ca2+) release from the endoplasmic reticulum (ER) controls numerous cellular functions including proliferation, and is regulated in part by inositol 1,4,5-trisphosphate receptors (IP3Rs). IP3Rs are ubiquitously expressed intracellular Ca2+-release channels found in many cell types. Although