A retroviral gene trap vector (U3Tkneo) that selects for integrations in or near expressed 5Π exons has been used to identify genes that are repressed during hematopoietic differentiation of mouse totipotent embryonic stem cells. The vector contains coding sequences for an HSV-thymidine kinase/neomy
Regulation of Id Gene Expression during Embryonic Stem Cell-Derived Hematopoietic Differentiation
β Scribed by M.M. Nogueira; M.T. Mitjavila-Garcia; F. Le Pesteur; M.D. Filippi; W. Vainchenker; A. Dubart Kupperschmitt; F. Sainteny
- Book ID
- 115586623
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 274 KB
- Volume
- 276
- Category
- Article
- ISSN
- 0006-291X
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Embryonic stem (ES) cells are derived from the inner cell mass of blastocysts, and in response to retinoic acid (RA) are induced to differentiate to form some of the first distinguishable cell types of early mammalian development. This makes ES cells an attractive model system for studying the initi