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Regulation of human biliary epithelial cell secretion by bile acids

✍ Scribed by N. Chignard; M. Mergey; D. Veissière; R. Parc; J. Capeau; R. Poupon; A. Paul; C. Housset

Book ID
119526127
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
106 KB
Volume
32
Category
Article
ISSN
0168-8278

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Biliary epithelial cells (cholangiocytes) are responsible for rapid regulation of bile volume and alkalinity. Secretin and other hormones raising intracellular cyclic adenosine monophosphate (cAMP) concentrations promote biliary HCO3 secretion by stimulating apical Cl- channels and Cl-/HCO3- exchang