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Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells

✍ Scribed by Luo, W; Wang, X; Kageshita, T; Wakasugi, S; Karpf, A R; Ferrone, S

Book ID
110070342
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
614 KB
Volume
25
Category
Article
ISSN
0950-9232

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## Abstract The lack of efficacy of available therapies for the treatment of malignant melanoma has emphasized the need to develop novel therapeutic strategies to prevent melanoma growth. We have tested whether the anti‐HMW‐MAA mAb 225.28S is able to inhibit human melanoma tumor growth in SCID mice