Regulation of herpes simplex virus type 1 thymidine kinase gene expression by thyroid hormone receptor in cultured neuronal cells
β Scribed by Shao-Chung V. Hsia; Rajeswara C. Pinnoji; Gautam R. Bedadala; James M. Hill; Jayavardhana R. Palem
- Book ID
- 111856309
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 275 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1355-0284
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## Abstract To analyze the site of integration of the herpes simplex virus type 1 (HSVβ1) thymidine kinase (TK) gene in biochemically transformed human cells, TKβHeLaβ(BU25) cells were transformed to the TK^+^ phenotype by a cloned, 2 kbp Pvull fragment of HSVβ1 DNA. The transformed cells [HeLa(BU2
Human non-small cell lung cancer (NSCLC) cells were transfected with recombinant prodrug herpes simplex virus type I thymidine kinase (HSV-tk) cDNA, and the selected clones underwent apoptosis in response to induction by antiviral ganciclovir (GCV). The efficiency of GCV-induced growth inhibition an