DNA synthesis in primary adult rat hepatocyte cultures was promoted by epidermal growth factor (EGF), arachidonic acid, and prostaglandins E2 and FLa (PGE2 and PGF2J. Growth promotion by EGF was blocked by 0.1 m M indomethacin and 1 m M aspirin, without affecting cell viability. If verapamil was pre
Regulation of hepatocyte proliferation
โ Scribed by G. Ruhenstroth-Bauer; M. Goldberg; S. Vogl
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 349 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0028-1042
No coin nor oath required. For personal study only.
โฆ Synopsis
After partial hepatectomy the low proliferation rate of hepatocytes increases dramatically. This is based on a feed-back system whose central link is a liver cell proliferation hormon, the so-called hepatopoietin. The hormon originates from the Peyer's patches: after their resection, the liver cell proliferation after partial hepatectomy decreases by about 80%. Hepatopoietin effects organ specific but species nonspecific.
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