Regulation of hepatic cholesterol biosynthesis by fatty acids: Effect of feeding olive oil on cytoplasmic acetoacetyl-coenzyme A thiolase, β-hydroxy-β-methylglutaryl-CoA synthase, and acetoacetyl-coenzyme A ligase

Regulation of early cholesterol biosynth

Regulation of early cholesterol biosynthesis in rat liver: Effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activities

✍ Akira Honda; Gerald Salen; Lien B. Nguyen; Guorong Xu; G. Stephen Tint; Ashok K. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB

Cytosolic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase catalyzes the formation of HMG-CoA, the substrate for the rate-controlling enzyme in the cholesterol biosynthetic pathway. To explore the regulation in liver, we developed a new, accurate, and reliable reversed-phase ion-pair chromat