Regulation of growth cone behavior by calcium: New dynamics to earlier perspectives
✍ Scribed by Gomez, Timothy M. ;Spitzer, Nicholas C.
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 254 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
Guidance of axons to their targets is in part due to the ability of motile growth cones to integrate signals generated through coincident interactions with multiple extracellular cues and to translate those signals into proper behavioral changes. Although many new axon guidance cues and their receptors have recently been discovered (for review see Goodman and Tessier-Lavigne, 1997), signaling through traditional second-messenger systems continues to emerge as a crucial intermediary for guidance. For example, changes in intracellular calcium concentration ([Ca 2ϩ ] i ), which have long been known to be capable of regulating axon outgrowth, have recently been found to act as key regulators of growth cone guidance in response to both biologically relevant factors in vitro and within intact and developing systems. This review summarizes recent reports linking changes in [Ca 2ϩ ] i with changes in growth cone behaviors in vitro and in vivo.