Regulation of glucocorticoid receptor gamma (GRγ) by glucocorticoid receptor haplotype and glucocorticoid
✍ Scribed by Adam Stevens; Rachelle Donn; David Ray
- Book ID
- 108703000
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 129 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0300-0664
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## Abstract We have established optimal conditions for the measurement of glucocorticoid receptors (GR) in human white cells using a whole‐cell binding assay with [^3^H]dexamethasone as the ligand, and the subsequent determination of the GR content in normal human lymphocytes and in leukemic cells
## Abstract A crucial step in the interaction of glucocorticoids with target cells is the activation step, which involves a conformational change in the cytoplasmic glucocorticoid–receptor protein complexes and facilitates their binding to the cell nucleus. Activation can be quantified by measuring