Regulation of Glial Development by Cell Line Derived Factors
β Scribed by JOEL M. LEVINE; CHANGLIN DOU
- Book ID
- 119865446
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 167 KB
- Volume
- 633
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Much attention has been paid to the ability of glial cell lineβderived neurotrophic factor (GDNF) to protect neurons from neurotoxic insults in the central nervous system (CNS). However, little is known about GDNF action on CNS glia that also can express GDNF receptor systems. In this s
Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is a more potent survival factor for dopaminergic neurons and the noradrenerg