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Regulation of genes encoding NAD(P)H:quinone oxidoreductases

โœ Scribed by Anil K Jaiswal

Book ID
114274463
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
393 KB
Volume
29
Category
Article
ISSN
0891-5849

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NAD(P)H:quinone oxidoreductase 1 (NQO1):
NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms
โœ David Ross; Jadwiga K Kepa; Shannon L Winski; Howard D Beall; Adil Anwar; David ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 139 KB

NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. This review focuses on detoxification reactions catalyzed by NQO1 and its role in antioxidant defense via the generation of antioxida