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Regulation of gating by negative charges in the cytoplasmic pore in the Kir2.1 channel

✍ Scribed by Lai-Hua Xie; Scott A. John; Bernard Ribalet; James N. Weiss

Book ID: 110113007
Publisher: Cambridge University Press
Year: 2004
Tongue: English
Weight: 348 KB
Volume: 561
Category: Article
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2004.072330

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## Abstract Mutations in Kir2.1 inwardly rectifying potassium channels are associated with Andersen syndrome, a disease characterized by potentially fatal cardiac arrhythmias. While several Andersen‐associated mutations affect membrane expression, the cytoplasmic signals that regulate Kir2.1 traffi