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Regulation of Fetal Hemoglobin Synthesis in the Hemoglobinopathies

✍ Scribed by DAVID G. NATHAN


Book ID
118722355
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
879 KB
Volume
445
Category
Article
ISSN
0890-6564

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## Abstract Fetal hemoglobin (HbF), the predominant hemoglobin in the fetus, is a mixture of two molecular species (Ξ±~2~^G^Ξ³~2~ and Ξ±~2~^A^Ξ³~2~) that differ only at position 136 reflecting the products of two nonallelic γ‐globin genes. At the time of birth, HbF accounts for ∼70% of the total Hb. Th